Titanium Dioxide – Its oral future?

EFSA rules Titanium Dioxide (E171) is no longer considered safe when used as a food additive (https://www.efsa.europa.eu/en/efsajournal/pub/6585). Here in the UK this opinion will be looked at carefully by the Foods Standards Agency and there is a good probability they will come to similar findings. Timings for this are unknown but is one to keep a watchful eye on.

So, if this is food related what about the relative safety in medicinal products? This ruling by EFSA may well drive the competent regulatory authorities to look at the risk to benefit of this ingredient in pharmaceuticals and set limitations or removal may be requested.

E171 is used as a pigment to add whiteness or to accentuate the depth and quality of a colour of tablets. It’s also employed to help in stability aspects within the formulation and a commonly used ingredient throughout industry.

This is one to watch closely as it may have a big impact on formulations currently approved.

James Hall